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Chemical Structure : LIMK-IN-22j
CAS No.: 1116571-01-7
Catalog No.: PC-70097Not For Human Use, Lab Use Only.
LIMK-IN-22j (LIMK-IN-1) is a potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LIMK-IN-22j (LIMK-IN-1) is a potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
LIMK-IN-22j (LIMK-IN-1) displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2.
LIMK-IN-22j (LIMK-IN-1) reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing).
| M.Wt | 453.348 | |
| Formula | C20H21BrN8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,Z)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide |
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1. Harrison BA, et al. J Med Chem. 2009 Nov 12;52(21):6515-8.
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