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LIMK1 and 2 dual inhibitor 1

Chemical Structure : LIMK1 and 2 dual inhibitor 1

CAS No.: 2215049-71-9

LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1)

Catalog No.: PC-35249Not For Human Use, Lab Use Only.

LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1) is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1) is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM).
    inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.

    Physicochemical Properties

    M.Wt 610.63
    Formula C28H21F3N6O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)-5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylacetamide

    References

    1. US Patent WO 2018055097.

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