LJ-4378 | A2AAR agonist, A3AR antagonist

Chemical Structure : LJ-4378

LJ-4378 (LJ4378)

Catalog No.: PC-25685Not For Human Use, Lab Use Only.

LJ-4378 is a dual-acting ligand with A2AAR agonist (EC50=80.3 nM for cAMP formation, binding Ki=7.19 nM) and A3 adenosine receptor (A3AR, binding Ki=11.8 nM) antagonist activity.

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Biological Activity

LJ-4378 is a dual-acting ligand with A2AAR agonist (EC50=80.3 nM for cAMP formation, binding Ki=7.19 nM) and A3 adenosine receptor (A3AR, binding Ki=11.8 nM) antagonist activity.

Physicochemical Properties

M.Wt	333.41
Formula	C15H19N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R)-2-(6-Amino-2-(hex-1-ynyl)-9H-purin-9-yl)- tetrahydrothiophene-3,4-diol

References

1. Kim K, et al. Int J Obes (Lond). 2022 Dec;46(12):2128-2136.

2. Xiyan Hou, et al. J Med Chem. 2012 Jan 12;55(1):342-56.

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LJ-4378 (LJ4378)

Biological Activity

Physicochemical Properties

References

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