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Chemical Structure : LJH-685
CAS No.: 1627710-50-2
Catalog No.: PC-45677Not For Human Use, Lab Use Only.
LJH-685 is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1,RSK2 and RSK3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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LJH-685 (LJH685) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1, RSK2 and RSK3 respectively.
LJH-685 (LJH685) inhibts Y-box binding protein-1 (YB-1) Ser102 phosphorylation (EC50=0.2-0.3 uM) in MDA-MB-231 cancer cells.
| M.Wt | 381.4185 | |
| Formula | C22H21F2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]- |
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1. Jain R, et al. J Med Chem. 2015 Sep 10;58(17):6766-83.
2. Aronchik I, et al. Mol Cancer Res. 2014 May;12(5):803-12.
3. Davies AH, et al. Oncotarget. 2015 Aug 21;6(24):20570-7.
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