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Chemical Structure : LLP-3
Catalog No.: PC-21421Not For Human Use, Lab Use Only.
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
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LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
LLP-3 does not affect the interaction of Survivin with other chromosomal passenger complex (CPC) proteins.
LLP-3 induces GBM cell apoptosis by inhibiting Survivin complex formation with Ran in a caspase- and p53 status–dependent manner.
LLP-3 inhibits Survivin interaction with Smac/DIABLO and small GTPase Ran.
LLP-3 induces apoptotic cell death in organotypic slice cultures of GBM surgical specimens.
LLP-3 abolishes the growth of patient-derived GBM spheres in vitro and in vivo.
| M.Wt | 535.00 | |
| Formula | C32H23ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guvenc H, et al. Clin Cancer Res. 2013 Feb 1;19(3):631-42.
2. Galiger C, et al. BMC Cancer. 2023 Nov 25;23(1):1148.
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