Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LMTK3 inibitor C28
CAS No.: 2764850-23-7
Catalog No.: PC-38206Not For Human Use, Lab Use Only.
LMTK3 inibitor C28 is a potent, ATP-competitive small-molecule inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 67 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LMTK3 inibitor C28 is a potent, ATP-competitive small-molecule inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 67 nM.
LMTK3 inibitor C28 displays high selectivity for LMTK3, only 18 of 140 kinases was reduced >50% in the presence of 1 μM, 4 kinases (CLK, 5 nM; DYRK1α, 6 nM; HIPK2, 48 nM; and IRAK4, 41 nM) have IC50 values of <50 nM.
LMTK3 inibitor C28 promotes proteasome-mediated degradation of LMTK3, an HSP90 client protein.
LMTK3 inibitor C28 exhibits potent anticancer activity in different human cancer cell lines (BC cells IC50=6.5-8.4 uM).
LMTK3 inibitor C28 inhibits tumor growth in orthotopic and transgenic mouse models of BC.
| M.Wt | 356.308 | |
| Formula | C18H11F3N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-(pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine |
|
1. Angeliki Ditsiou, et al. Sci Adv. 2020 Nov 13;6(46):eabc3099.
2. Chiara Cilibrasi, et al. Mol Cancer. 2021 Mar 17;20(1):53.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
