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Chemical Structure : LN-1-255
Catalog No.: PC-61937Not For Human Use, Lab Use Only.
LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor.
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LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor; inhibits SHV-1 and SHV-2 beta-lactamases with Ki of 110 nM and 100 nM, significantly enhances the activity of ceftazidime and cefpirome against extended-spectrum cephalosporin and Sme-1 containing carbapenem-resistant clinical strains; also inhibits the class D carbapenemase OXA-48 with IC50 of 3 nM, an important emerging mechanism of antibiotic resistance.
| M.Wt | 510.449 | |
| Formula | C22H19N2NaO9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pattanaik P, et al. J Biol Chem. 2009 Jan 9;284(2):945-53.
2. Vallejo JA, et al. J Antimicrob Chemother. 2016 Aug;71(8):2171-80.
3. Vázquez-Ucha JC, et al. Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01172-17.
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