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Chemical Structure : LP-182
Catalog No.: PC-49266Not For Human Use, Lab Use Only.
LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways.
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LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways.
LP-182 displays >100-fold selectivity against a broad panel of 321 human protein kinases.
LP-182 ameliorated of splenomegaly and fibrotic disease phenotypes, and extended overall survival in the myeloproliferative leukemia oncogene (MPL W515L) mouse model of myelofibrosis (MF).
Oral treatment of MPLW515L mice with LP-182 also resulted in renormalization of blood cell populations and attenuation of downstream protein kinase B (PKB/AKT) and extracellular signalregulated protein kinase 1/2 (ERK1/2) signaling activity in bone marrow and isolated splenocytes.
| M.Wt | 1093.287 | |
| Formula | C45H42ClF4IN8O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brian D Ross, et al. Nat Commun. 2022 Aug 17;13(1):4730.
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