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Chemical Structure : LPA2 antagonist 58
Catalog No.: PC-20462Not For Human Use, Lab Use Only.
LPA2 antagonist 58 is a highly potent and selective LPA2 receptor antagonist with pIC50 of 8.22 (hLPA2) and 8.19 (mLPA2), >1000-fold selectivity over LPA1 receptor.
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LPA2 antagonist 58 is a highly potent and selective LPA2 receptor antagonist with pIC50 of 8.22 (hLPA2) and 8.19 (mLPA2), >1000-fold selectivity over LPA1 receptor.
LPA2 antagonist 58 also highly selective against LPA3 and LPA5 isoforms (pIC50 < 4.30 for both receptors).
LPA2 antagonist 58 exhibits free exposure in lung after oral administration.
| M.Wt | 656.80 | |
| Formula | C30H37FN8O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Armani E, et al. J Med Chem. 2023 Apr 5. doi: 10.1021/acs.jmedchem.2c02087.
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