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Chemical Structure : LSN3318839
Catalog No.: PC-20512Not For Human Use, Lab Use Only.
LSN3318839 is a potent, positive allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 14 nM, Emax of 104%.
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LSN3318839 is a potent, positive allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 14 nM, Emax of 104%.
LSN3318839 increases the potency and efficacy of the weak metabolite GLP-1(9-36)NH2 to become a full agonist at the GLP-1R and modestly potentiates the activity of the highly potent full-length ligand, GLP-1(7-36)NH2.
LSN3318839 preferentially enhances G protein-coupled signaling by the GLP-1R over β-arrestin recruitment.
LSN3318839 demonstrates robust glucose lowering in animal models alone or in treatment combination with sitagliptin.
| M.Wt | 480.39 | |
| Formula | C26H23Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Francis S Willard, et al. J Med Chem. 2021 Mar 25;64(6):3439-3448.
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