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LV-320

Chemical Structure : LV-320

CAS No.: 2449093-46-1

LV-320 (LV320;LV 320)

Catalog No.: PC-35540Not For Human Use, Lab Use Only.

LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.

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Biological Activity

LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assay.
LV-320 binds to ATG4B and is an uncompetitive inhibitor of ATG4B with Kd of 16 uM.
LV-320 blocks starvation-induced autophagic fux in vitro; also inhibit ATG4A with an IC50 of 35.5 uM, but does not shows meaningful inhibition for caspase-3 or cathepsin B.
LV-320 reduces autophagic fux in vitro and is bioavailable and active in vivo.
LV-320 is a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.

Physicochemical Properties

M.Wt 520.102
Formula C29H26ClNO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(((4-(2-(7-chloroquinolin-4-yl)vinyl)phenyl)(phenethylthio)methyl)thio)propanoic acid

References

1. Bosc D, et al. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.

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