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Chemical Structure : LX7101
CAS No.: 1192189-69-7
Catalog No.: PC-43141Not For Human Use, Lab Use Only.
LX7101 is a potent, dual LIMK and ROCK inhibitor with IC50 of 4.3/32//69/32/ nM for LIMK2/LIMK1/ROCK1/ROCK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LX7101 is a potent, dual LIMK and ROCK inhibitor with IC50 of 4.3/32//69/32/ nM for LIMK2/LIMK1/ROCK1/ROCK2, respectively.
LX7101 exhibits good kinase selectivity in a panel of binding assays including 78 different receptors and transporters at Cerep (only 5 have >60% inhibition at 10 uM).
LX7101 demonstrates high efficacy in mouse model of ocular hypertension, ans shows potential for the treatment of glaucoma.
| M.Wt | 451.5215 | |
| Formula | C23H29N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 24 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N,N-dimethyl-, 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester |
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1. Harrison BA, et al. ACS Med Chem Lett. 2014 Nov 24;6(1):84-8.
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