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LY 2979165

Chemical Structure : LY 2979165

CAS No.: 311385-35-9

LY 2979165 (MP-101;LY2979165)

Catalog No.: PC-62593Not For Human Use, Lab Use Only.

LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist; suppresses glutamate release at presynaptic receptors during periods of enhanced, abnormal, glutamate activity and has potential for use in treating psychiatric and neurologic disorders

Alzheimer Disease

Phase 2 Clinical

Physicochemical Properties

M.Wt 355.369
Formula C13H17N5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,2S,4R,5R,6R)-4-((4H-1,2,4-triazol-3-yl)thio)-2-((S)-2-aminopropanamido)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

References

1. McColm J, et al. Br J Clin Pharmacol. 2017 Aug;83(8):1654-1667.

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