Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LY3020371 hydrochloride
Catalog No.: PC-60730Not For Human Use, Lab Use Only.
A potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively; exhibits little to no agonist or antagonist activity against mGlu1/4/5/6/7/8 (>1 uM potenct); potently blocks mGlu2/3 agonist (DCG-IV)-inhibited, forskolin-stimulated cAMP formation with IC50 of 16.2 nM, blocks agonist-suppressed spontaneous Ca2+ oscillations (IC50= 34 nM) and in an intact hippocampal slice preparation (IC50= 46 nM); exerts an antidepressant-like signature in vivo.
| M.Wt | 395.802 | |
| Formula | C15H16ClF2NO5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Chappell MD, et al. Med Chem. 2016 Dec 22;59(24):10974-10993.
2. Witkin JM, et al. Neuropharmacology. 2017 Mar 15;115:100-114.
3. Witkin JM, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86.
4. Witkin JM, et al. Pharmacol Biochem Behav. 2017 Apr;155:43-55.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
