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Chemical Structure : LY354740
CAS No.: 176199-48-7
Catalog No.: PC-45568Not For Human Use, Lab Use Only.
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM.
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $398 | In stock | |
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LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM.
LY354740 possesses no activity at iGluR or group 1 mGluR (>100 uM).
LY354740 shows anticonvulsant and anxiolytic properties in vivo; orally active.
| M.Wt | 185.1772 | |
| Formula | C8H11NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 1.9 mg/mL |
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| Chemical Name/SMILES |
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- |
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1. Monn JA, et al. J Med Chem. 1997 Feb 14;40(4):528-37.
2. Menezes MM, et al. Neurosci J. 2013;2013:736439.
3. Profaci CP, et al. Psychopharmacology (Berl). 2011 Jul;216(2):235-43.
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