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Chemical Structure : LY500307
CAS No.: 533884-09-2
Catalog No.: PC-35370Not For Human Use, Lab Use Only.
LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $288 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency.
LY500307 reduces proliferation and induces apoptosis in GBM cells, enhances ERβ signaling and expression.
LY500307 modulates the expression of genes involved in cell cycle, cell death, survival, and DNA damage response.
LY500307 also sensitizes GBM cells to chemotherapeutic agents, reduces GBM progression in an orthotopic model.
| M.Wt | 282.339 | |
| Formula | C18H18O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol |
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1. Sareddy GR, et al. Sci Rep. 2016 Apr 29;6:24185.
2. Zhao L, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.
3. Reese JM, et al. Oncotarget. 2017 Oct 11;8(57):96506-96521.
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