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Chemical Structure : LYN-1604
CAS No.: 2088939-99-3
Catalog No.: PC-63085Not For Human Use, Lab Use Only.
LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM.
LYN-1604 induces cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells.
LYN-1604 induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
LYN-1604 inhibits the tumor growth of xenograft TNBC.
| M.Wt | 584.626 | |
| Formula | C33H43Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]- |
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1. Zhang L, et al. Chem Sci. 2017 Apr 1;8(4):2687-2701.
2. Ouyang L, et al. Autophagy. 2017 Apr 3;13(4):777-778.
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