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Lactacystin

Chemical Structure : Lactacystin

CAS No.: 133343-34-7

Lactacystin

Catalog No.: PC-24468Not For Human Use, Lab Use Only.

Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.

Physicochemical Properties

M.Wt 376.42
Formula C15H24N2O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-Acetyl-S-((2R,3S,4R)-3-hydroxy-2-((S)-1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl)-L-cysteine

References

1. Omura S, et al. J Antibiot (Tokyo). 1991 Jan;44(1):113-6.

2. Oda K, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):800-5.

3. Fenteany G, et al. Science. 1995 May 5;268(5211):726-31.

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