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Chemical Structure : Lanperisone
Catalog No.: PC-62036Not For Human Use, Lab Use Only.
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.
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Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.
| M.Wt | 285.305 | |
| Formula | C15H18F3NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8.
2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87.
3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.
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