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Chemical Structure : Laropiprant
CAS No.: 571170-77-9
Catalog No.: PC-45826Not For Human Use, Lab Use Only.
A potent and selective prostaglandin D2 (PGD2) receptor (DP1) antagonist with Ki of 0.57 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $156 | In stock | |
| 50 mg | $560 | In stock | |
| 100 mg | $680 | In stock |
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A potent and selective prostaglandin D2 (PGD2) receptor (DP1) antagonist with Ki of 0.57 nM; shows weaker affinity for TP (Ki=2.95 nM), no significant activity on EP1, EP2, EP3, EP4, FP, and IP; inhibits the accumulation of cAMP in washed platelets and in plateletrich plasma challenged with PGD with IC50 of 0.09 nM and 4 nM, respectively; displays an excellent rat pharmacokinetic profile and efficacious in a sheep model of allergic rhinitis.
Dyslipidemia
Withdrawn
| M.Wt | 435.8963 | |
| Formula | C21H19ClFNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)- |
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1. Sturino CF, et al. J Med Chem. 2007 Feb 22;50(4):794-806.
2. Cheng K, et al. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.
3. Philip G, et al. J Allergy Clin Immunol. 2009 Nov;124(5):942-8.e1-9.
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