Lefamulin (BC-3781) | Antibiotic | Probechem Biochemicals

Chemical Structure : Lefamulin

CAS No.: 1061337-51-6

Lefamulin (BC3781, BC-3781)

Catalog No.: PC-22410Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$298	In stock
25 mg	$478	In stock
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Biological Activity

Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.
Lefamulin (BC-3781) exhibits a log-normal MIC distribution against the population of S. pneumoniae, with modal MIC, MIC50, and MIC90 results of 0.12, 0.12, and 0.25 μg/ml, respectively.
Lefamulin (BC-3781) exhibits potent antibacterial activity against the most important respiratory and skin pathogens, including Streptococcus spp. and Staphylococcus spp., fastidious Gram-negative organisms, such as Haemophilus influenzae, and atypical respiratory pathogens, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.

Physicochemical Properties

M.Wt	507.73
Formula	C28H45NO5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate

References

1. Waites KB, et al. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02008-16.

2. Rubino CM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):282-8.

Lefamulin (BC3781, BC-3781)

Biological Activity

Physicochemical Properties

References

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