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Lenabasum

Chemical Structure : Lenabasum

CAS No.: 137945-48-3

Lenabasum (Ajulemic acid;IP-751;Anabasum)

Catalog No.: PC-61381Not For Human Use, Lab Use Only.

A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ; produces significant antitumor activity and effects its actions primarily via CB(2) receptors; inhibits interleukin-8 promoter activity in a PPARgamma-dependent manner; significantly suppresses CYP-induced urinary frequency in rats at 10 mg/kg.

Fibrosis

Phase 2 Clinical

Physicochemical Properties

M.Wt 400.559
Formula C25H36O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-9-carboxylic acid

References

1. Recht LD, et al. Biochem Pharmacol. 2001 Sep 15;62(6):755-63.

2. Ambrosio AL, et al. J Biol Chem. 2007 Jun 22;282(25):18625-33.

3. Johnson DR, et al. J Cell Biochem. 2007 Jan 1;100(1):184-90.

4. Hiragata S, et al. Urology. 2007 Jul;70(1):202-8.

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