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Chemical Structure : Leptomycin B
Catalog No.: PC-70229Not For Human Use, Lab Use Only.
A potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1).
| Packing | Price | Stock | Quantity |
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Bulk size, bulk discount!
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A potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1); blocks the cell cycle and shows potent anti-tumor activity, blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and inhibits the inactivation of p53.
| M.Wt | 504.74 | |
| Formula | C33H48O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fornerod M, et al. Cell. 1997 Sep 19;90(6):1051-60.
2. Kudo N, et al. Exp Cell Res. 1998 Aug 1;242(2):540-7.
3. Ossareh-Nazari B, et al. Science. 1997 Oct 3;278(5335):141-4.
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