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Chemical Structure : Lethal toxin inhibitor DN1
Catalog No.: PC-35825Not For Human Use, Lab Use Only.
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively.
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Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively.
DN1 protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation.
DN1 also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
| M.Wt | 257.268 | |
| Formula | C14H12FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231.
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