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Levocabastine hydrochloride

Chemical Structure : Levocabastine hydrochloride

CAS No.: 79547-78-7

Levocabastine hydrochloride (R 50547)

Catalog No.: PC-26998Not For Human Use, Lab Use Only.

Levocabastine hydrochloride (R 50547) is a potent and selective histamine H1-receptor (H1R) antagonist, is also a selective, high affinity neurotensin receptor subtype 2 (NTSR2, NTS2) antagonist with Ki of 17 nM for mNTRS2.

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Biological Activity

Levocabastine hydrochloride (R 50547) is a potent and selective histamine H1-receptor (H1R) antagonist, is also a selective, high affinity neurotensin receptor subtype 2 (NTSR2, NTS2) antagonist with Ki of 17 nM for mNTRS2.

Physicochemical Properties

M.Wt 456.99
Formula C26H30ClFN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S,4R)-1-((1s,4R)-4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid hydrochloride

References

1. Folkerts G, et, al. Br J Pharmacol. 1993 Apr;108(4):1083-93.

2. Qasem AR, et, al. Biochem Pharmacol. 2008 Sep 15;76(6):751-62.

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