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Lexacalcitol

Chemical Structure : Lexacalcitol

CAS No.: 131875-08-6

Lexacalcitol (KH-1060)

Catalog No.: PC-45802Not For Human Use, Lab Use Only.

Aa potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Aa potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy; stimulates the synthesis of sulphated glycosaminoglycans and hydroxyproline in skin treated with betamethasone; strongly stimulated the expression of TGF-beta 1 in betamethasone-impaired granulation tissue; a potent vitamin D receptor agonist.

Physicochemical Properties

M.Wt 460.689
Formula C29H48O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-

References

1. Gniadecki R, et al. Br J Pharmacol. 1994 Oct;113(2):439-44.

2. Gniadecki R, et al. J Endocrinol. 1994 Jun;141(3):411-5.

3. Sandler S, et al. Immunol Lett. 1994 Jun;41(1):73-7.

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