Lexacalcitol | Vitamin D analog | Probechem Biochemicals

Chemical Structure : Lexacalcitol

Lexacalcitol (KH-1060, KH1060)

Catalog No.: PC-45802Not For Human Use, Lab Use Only.

Lexacalcitol (KH1060) is a potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.

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Biological Activity

Lexacalcitol (KH1060) is a potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.
Lexacalcitol stimulates the synthesis of sulphated glycosaminoglycans and hydroxyproline in skin treated with betamethasone.
Lexacalcitol strongly stimulated the expression of TGF-beta 1 in betamethasone-impaired granulation tissue; a potent vitamin D receptor agonist.

Physicochemical Properties

M.Wt	460.689
Formula	C29H48O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-

References

1. Gniadecki R, et al. Br J Pharmacol. 1994 Oct;113(2):439-44.

2. Gniadecki R, et al. J Endocrinol. 1994 Jun;141(3):411-5.

3. Sandler S, et al. Immunol Lett. 1994 Jun;41(1):73-7.

Lexacalcitol (KH-1060, KH1060)

Biological Activity

Physicochemical Properties

References

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