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Chemical Structure : Libvatrep
CAS No.: 871814-52-7
Catalog No.: PC-38676Not For Human Use, Lab Use Only.
Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain.
SAF312 is >150-fold selective for TRPV1 when tested against a panel of 18 TRP channels.
SAF312 inhibited capsaicin, low pH 2-(n-morpholino)ethanesulfonic acid (MES, pH 5.5), anandamide (AEA), and N-arachidonoyl dopamine (NADA) stimulated human TRPV1 with IC50 values of 12, 16, 7.3 and 36 nM, respectively in a selective, non-competitive, and reversible manner.
| M.Wt | 305.337 | |
| Formula | C18H15N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile |
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1. Quint Medley, et al. ARVO Annual Meeting Abstract, June 2021. In-vitro and In-vivo pharmacology of SAF312 as a TRPV1 inhibitor for ocular surface pain.
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