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Chemical Structure : Lifitegrast
CAS No.: 1025967-78-5
Catalog No.: PC-45616Not For Human Use, Lab Use Only.
A potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 50 mg | $352 | In stock | |
| 100 mg | $592 | In stock | |
| 200 mg | $992 | In stock |
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A potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells; exhibits good in vitro safety profile and low potency on CYP3A4, CYP2C9 and hERG; development as an ophthalmic solution for treating dry eye.
Other Indication
Approved
| M.Wt | 615.4811 | |
| Formula | C29H24Cl2N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)- |
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1. Zhong M, et al. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6.
2. Sun Y, et al. J Ocul Pharmacol Ther. 2013 May;29(4):395-402.
3. Semba CP, et al. Clin Ophthalmol. 2016 Jun 10;10:1083-94.
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