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Chemical Structure : Liquidambaric acid
CAS No.: 4481-62-3
Catalog No.: PC-20658Not For Human Use, Lab Use Only.
Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $198 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.
TRAF2 is a positive regulator of Wnt/β-catenin signaling and colon cancer.
Liquidambaric acid disrupts the interaction between TRAF2 and β-catenin in both MST and coIP assays.
Liquidambaric acid inhibits TRAF2/β-catenin/TCF4/TNIK complex formation in colon cancer.
| M.Wt | 454.70 | |
| Formula | C30H46O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,3aR,5aS,5bS,7aS,11aS,11bS,13aS,13bS)-5a,5b,8,8,11a-pentamethyl-9-oxo-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid |
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1. Yan R, et al. Cell Rep. 2022 Feb 1;38(5):110319.
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