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Chemical Structure : Livoletide
Catalog No.: PC-61386Not For Human Use, Lab Use Only.
A first-in-class analogue of unacylated ghrelin, and unacylated ghrelin receptor agonist.
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A first-in-class analogue of unacylated ghrelin, and unacylated ghrelin receptor agonist; exhibits the same pharmacological profile as UAG both in vitro and in vivo, independently of AG receptor binding; prevents HFD-induced proinflammatory effects, stimulates expression of mitochondrial function markers in brown adipose tissue, and prevents development of a prediabetic metabolic state; also prevents a HFD-induced increase in acyl ghrelin levels.
Diabetes
Phase 1 Clinical
| M.Wt | 962.036 | |
| Formula | C40H63N15O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Julien M, et al. Eur J Pharm Sci. 2012 Nov 20;47(4):625-35.
2. Delhanty PJ, et al. FASEB J. 2013 Apr;27(4):1690-700.
3. Callaghan B, et al. Br J Pharmacol. 2014 Mar;171(5):1275-86.
4. Allas S, et al. Diabetes Obes Metab. 2016 Sep;18(9):868-74.
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