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Chemical Structure : Lu AF60097
Catalog No.: PC-20763Not For Human Use, Lab Use Only.
Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).
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Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).
Lu AF60097 inhibited [3H]5-HT uptake with an IC50 of 207 nM in hSERT expressed in COS-7 cells.
Lu AF60097 and imipramine can block SERT synergistically.
Lu AF60097 (250 nM) increases hippocampal 5-HT levels in rat hippocampus.
| M.Wt | 525.62 | |
| Formula | C32H32FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Per Plenge, et al. Nature Communications volume 11, Article number: 1491 (2020)
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