Lucanthone

Chemical Structure : Lucanthone

CAS No.: 479-50-5

Catalog No.: PC-60602Not For Human Use, Lab Use Only.

Lucanthone is an ionizing radiation enhancer and apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with IC50 of 5 uM for inhibition of APE1 incision of depurinated plasmid DNA, also may act as an inhibitor of protein palmitoyl thioesterase 1 (PPT1).

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Biological Activity

Lucanthone is an ionizing radiation enhancer and apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with IC50 of 5 uM for inhibition of APE1 incision of depurinated plasmid DNA, also may act as an inhibitor of protein palmitoyl thioesterase 1 (PPT1).

Lucanthone slows GBM by inhibiting autophagic flux through lysosome targeting and decreases the number of Olig2+ glioma stem-like cells (GSC) in vitro and in vivo.

Lucanthone efficiently abates stemness in patient-derived GSC and reduces tumor microtube formation in GSC, an emerging hallmark of treatment resistance in GBM.

Lucanthone is an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy; induces lysosomal membrane permeabilization, and possesses significantly more potent activity in breast cancer models compared with chloroquine; induces cathepsin D-mediated apoptosis.

Physicochemical Properties

M.Wt	340.485
Formula	C20H24N2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl- (6CI,8CI)

References

1. Carew JS, et al. J Biol Chem. 2011 Feb 25;286(8):6602-13.

2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

Lucanthone

Biological Activity

Physicochemical Properties

References

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