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Chemical Structure : Luxeptinib
Catalog No.: PC-72114Not For Human Use, Lab Use Only.
Luxeptinib (CG-806) is an orally bioavailable multikinase inhibitor with nanomolar potency against BTK, FLT3, TRK, STE/MAPK and Aurora kinase clusters.
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Luxeptinib (CG-806) is an orally bioavailable multikinase inhibitor with nanomolar potency against BTK, FLT3, TRK, STE/MAPK and Aurora kinase clusters.
Luxeptinib (CG-806) is cytotoxic to primary malignant cells obtained from patients with AML, ALL, and CLL at lower concentrations than other BTK and FLT3 inhibitors, and has activity in AML and lymphoma xenografts at concentrations attainable in patients.
Luxeptinib inhibited the release of IL-1β, IL-6 and TNFα from THP-1 monocytes and macrophages at concentrations of 1 uM or above.
Luxeptinib (CG-806) also inhibits the kinases p38MAPK, ERK1/2, SAPK/JNK and activation of transcription factor NF-κBp65 with a concentration profile similar to its inhibition of cytokine release.
| M.Wt | 495.438 | |
| Formula | C25H17F4N5O2 | |
| Appearance | Solid | |
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1. Zheng TJ, et al. Am J Physiol Cell Physiol. 2021 May 1;320(5):C902-C915.
2. Sonowal H, et al. Biochem Pharmacol. 2022 Jan;195:114861.
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