M-1001 (M1001)

Chemical Structure : M-1001

CAS No.: 874590-32-6

Catalog No.: PC-28042Not For Human Use, Lab Use Only.

M-1001 (M1001) is an allosteric small molecule agonist of HIF-2alpha (HIF2α), binds to the HIF-2α PAS-B domain with MST KD of 667 nM.

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Biological Activity

M-1001 (M1001) is an allosteric small molecule agonist of HIF-2alpha (HIF-2α), binds to the HIF-2α PAS-B domain with MST KD of 667 nM.

M.Wt	327.40
Formula	C17H17N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2-(Pyrrolidin-1-yl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide

1. Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25.