M119

Chemical Structure : M119

Catalog No.: PC-27336Not For Human Use, Lab Use Only.

M119 is a specific inhibitor of G protein beta gamma subunit Gβγ, inhibits Gβγ-mediated signalling, interferes with Gβγ binding to GRK2, thereby inhibiting GRK2 membrane localization and Gβγ-mediated GPCR phosphorylation.

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Biological Activity

Physicochemical Properties

M.Wt	370.36
Formula	C20H18O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,5,6-Trihydroxy-3-oxo-3H-xanthen-9-yl)cyclohexane-1-carboxylic acid

References

1. Tabetha M Bonacci, et al. Science. 2006 Apr 21;312(5772):443-6.

2. Mathews JL, et al. J Neurosci. 2008 Nov 19;28(47):12183-9.

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M119

Biological Activity

Physicochemical Properties

References

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