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Chemical Structure : M4K2304
Catalog No.: PC-22014Not For Human Use, Lab Use Only.
M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.
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M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.
M4K2304 shows cell IC50 of 11 nM in NanoBRET target engagement assay.
M4K2304 also shows high selectivity over ALK1 and ALK6, ALK4, as well as favorable kinome-wide selectivity.
M4K2304 demonstrates excellent kinome-wide selectivity, inhibiting only 3% of 422 kinases by more than 50% at 1 uM.
| M.Wt | 460.58 | |
| Formula | C27H32N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. González-Álvarez H, et al. J Med Chem. 2024 Mar 18.
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