Chemical Structure : MAC-0452936
CAS No.:
257863-06-2
MAC-0452936
(MAC0452936)
Catalog No.: PC-23136Not For Human Use, Lab Use Only.
MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
MAC-0452936 inhibits Lgt activity with an IC50 of 0.59 μM and 1.45 μM for Lgt purified using amphipol and DDM lipid matrices, respectively.
MAC-0452936 inhibits the growth of E. coli through inhibition of Lgt.
MAC-0452936 demonstrates potent activity against wild-type isolates of E. coli and S. Tm when combined with the antibiotic adjuvant SPR741, but not Gram-negative pathogens A. baumannii, K. pneumoniae, K. aerogenes, or P. aeruginosa.
Physicochemical Properties
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M.Wt
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317.40
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Formula
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C17H19NO3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,2-Dimethyl-1-(2-thienyl)-1-propanone O-(4-methoxybenzoyl)oxime
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References
1. Rachwalski K, et al. iScience. 2024 Sep 5;27(10):110894.
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