Catalog No.: PC-72426Not For Human Use, Lab Use Only.
MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
MAC-545496 could also serve as an antivirulence agent alone.
MAC-545496 attenuates MRSA virulence in Galleria mellonella larvae.
MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.
GraR is a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance.
MAC-545496 has value as a research tool to probe the GraXRS regulatory system and as an antibacterial lead series of a mechanism to combat drug-resistant Staphylococcal infections.
