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Chemical Structure : MAC-5576
Catalog No.: PC-73340Not For Human Use, Lab Use Only.
MAC-5576 (MAC5576) is a small molecule, covalent inhibitor of coronavirus SARS-CoV 3CLpro with IC50 of 0.5 uM, inhibits SARS-CoV-2 3CL protease with IC50 of 0.093 uM.
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MAC-5576 (MAC5576) is a small molecule, covalent inhibitor of coronavirus SARS-CoV 3CLpro with IC50 of 0.5 uM, inhibits SARS-CoV-2 3CL protease with IC50 of 0.093 uM.
MAC-5576 inhibits Hepatitis A virus (HAV) 3Cpro with IC50 of 0.54 uM.
MAC-5576 selectively binds to the active site cysteine 145 of the SARS-CoV-2 3CL protease.
| M.Wt | 239.673 | |
| Formula | C10H6ClNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jan E Blanchard, et al. Chem Biol. 2004 Oct;11(10):1445-53.
2. Hengrui Liu, et al. Nat Commun. 2022 Apr 7;13(1):1891.
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