Catalog No.: PC-20744Not For Human Use, Lab Use Only.
MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis.
MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis.
MAC13772 is effective against antibiotic-resistant pathogens.
MAC13772 is capable of dampening the viability of carbapenem-resistant P. aeruginosa (CRPA).
MAC13772 interferes the production of pyocyanin, an important virulence factor of P. aeruginosa.
Physicochemical Properties
M.Wt
227.24
Formula
C8H9N3O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-((2-nitrophenyl)thio)acetohydrazide
References
1. Zlitni S, et al. Nat Chem Biol. 2013 Dec;9(12):796-804.
2. Carfrae LA, et al. Nat Microbiol. 2020 Jan;5(1):93-101.
3. Shi Y, et al. PLoS Pathog. 2023 Jan 23;19(1):e1011110.
