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Chemical Structure : MAL3-101
Catalog No.: PC-62566Not For Human Use, Lab Use Only.
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.
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MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM; also exhibits antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients.
| M.Wt | 931.14 | |
| Formula | C54H66N4O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fewell SW, et al. J Biol Chem. 2004 Dec 3;279(49):51131-40.
2. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62.
3. Braunstein MJ, et al. J Oncol. 2011;2011:232037. doi: 10.1155/2011/232037.
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