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Chemical Structure : MALT1 inhibitor MI-2
CAS No.: 1047953-91-2
Catalog No.: PC-42938Not For Human Use, Lab Use Only.
MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.
MALT1 inhibitor MI-2 inhibits cleavage of MALT1 substrates, which is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation.
MALT1 inhibitor MI-2 specifically suppresses ABC-DLBCL in vitro and in vivo.
MALT1 inhibitor MI-2 exhibits GI 50 of 0.2, 0.5, 0.4, and 0.4 uM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells respectively, inhibits nuclear translocation of RelB and p50, and decreases Bcl-xL levels in CLL cells.
| M.Wt | 455.7223 | |
| Formula | C19H17Cl3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Acetamide, 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]- |
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2. Saba NS, et al. Cancer Res. 2017 Dec 15;77(24):7038-7048.
3. Liu W, et al. Oncotarget. 2016 May 24;7(21):30536-49.
4. Yeh CN, et al. Oncotarget. 2017 Dec 8;8(69):113444-113459.
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