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Chemical Structure : MAM03055A
Catalog No.: PC-47095Not For Human Use, Lab Use Only.
MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM.
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MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM.
MAM03055A displays weak affinity against sigma-1 receptor with Ki of 3371 nM.
MAM03055A potently induced cell death in SK-N-SH neuroblastoma, MDA-MB-231 breast, and both SW48 and SW480 colorectal cancer cell lines, causing proapoptotic BH3 interacting-domain death agonist (BID) cleavage in SK-N-SH cells.
MAM03055A bound pseudo-irreversibly to sigma-2 receptors and caused residual cytotoxic activity after acute exposure and removal of the compound from the media.
MAM03055A also induced a time-dependent loss of sigma-2 receptor/TMEM97 protein from cells.
| M.Wt | 810.966 | |
| Formula | C43H48F2N8O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu CZ, et al. Eur J Pharmacol. 2021 Sep 5;906:174263.
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