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MAO-B inhibitor 8f

Chemical Structure : MAO-B inhibitor 8f

CAS No.: 947540-06-9

MAO-B inhibitor 8f

Catalog No.: PC-61487Not For Human Use, Lab Use Only.

A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM; shows no significant activity over MAO-A (>10 uM); shows improvement for memory in multiple animal models, has an excellent profile against a panel of other enzymes and receptors, good pharmacokinetic properties in rodents and dogs.

Physicochemical Properties

M.Wt 359.367
Formula C15H16F3N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4-hydroxypiperidin-1-yl)(5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophen-2-yl)methanone

References

1. Kaplan A, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758.

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