Chemical Structure : MAR-3.6.2
CAS No.:
927270-10-8
MAR-3.6.2
Catalog No.: PC-26550Not For Human Use, Lab Use Only.
MAR-3.6.2 is a specific small molecule, allosteric inhibitor of small GTPase RAN (RAS-related nuclear protein), targets RAN a cryptic pocket and disrupts its on-state and nuclear export, decreases miR-126 biogenesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MAR-3.6.2 is a specific small molecule, allosteric inhibitor of small GTPase RAN (RAS-related nuclear protein), targets RAN a cryptic pocket and disrupts its on-state and nuclear export, decreases miR-126 biogenesis.
MAR-3.6.2 reduces RAN GTP binding in HUVEC ECS.
MAR-3.6.2 has no measurable impact on the GTP-binding activity of related small GTPases, including RAS and RAB5.
MAR-3.6.2 disrupted RAN interaction with RCC1 and trapped RAN-GDP in the nucleus, decreased nucleus-to-cytoplasm export of pre-miR-126 and mature miR-126 biogenesis.
MAR-3.6.2 demonstrated dose-dependent inhibition of cell proliferation and induction of apoptosis across multiple AML cell lines.
MAR-3.6.2 (25 mg/kg, IV, daily for 3 weeks) exhibited significant antileukemic activity in the MllPTD/WT/Flt3ITD/ITD AML mouse model.
Physicochemical Properties
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M.Wt
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372.44
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Formula
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C19H20N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3,8-dimethyl-3-(2-(o-tolylamino)thiazol-4-yl)-2,7-dioxaspiro[4.4]nonane-1,6-dione
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References
1. Valerio M, et al. Commun Biol. 2026 Apr 14. doi: 10.1038/s42003-026-10026-0.
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