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Chemical Structure : MAT-POS-e194df51-1
Catalog No.: PC-21335Not For Human Use, Lab Use Only.
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
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MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
MAT-POS-e194df51-1 shows good cross-reactivity against known circulating variants of SARS-CoV-2 in antiviral cellular assays in a CPE assay in HeLa-ACE2 cells, including SARS-CoV-2 variants Alpha, Beta, Delta, and Omicron.
MAT-POS-e194df51-1 shows antiviral activity EC50 of 126 nM in HeLa-ACE2 cells without measurable cytotoxicity.
MAT-POS-e194df51-1 shows the distinct Mpro binding site compared to approved Mpro inhibitors nirmatrelvir and ensitrelvir (S-217622).
MAT-POS-e194df51-1 exhibits favorable properties required for an orally bioavailable inhibitor.
| M.Wt | 480.97 | |
| Formula | C24H21ClN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Melissa L Boby, et al. Science. 2023 Nov 10;382(6671):eabo7201.
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