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Chemical Structure : MBQ-167
CAS No.: 2097938-73-1
Catalog No.: PC-60905Not For Human Use, Lab Use Only.
MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
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| 100 mg | Get quote |
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MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells.
MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities.
MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation; decreases metastatic cancer cell viability with GI50 of 130 nM without affecting noncancer mammary epithelial cells, and causes G2-M cell-cycle arrest and subsequent apoptosis.
MBQ-167 inhibits mammary tumor growth and metastasis in immunocompromised mice.
| M.Wt | 338.414 | |
| Formula | C22H18N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole |
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1. Humphries-Bickley T, et al. Mol Cancer Ther. 2017 May;16(5):805-818.
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