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Chemical Structure : MBX-4055
Catalog No.: PC-49005Not For Human Use, Lab Use Only.
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.
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MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.
MBX-4055 is active against divergent human parasite strains, with improved oral absorption with acceptable in vivo tolerability and pharmacokinetics.
MBX-4055 is highly specific for the PSAC target without activity against a battery of human channels, enzymes and receptors, is refractory to acquired resistance during extended in vitro selection.
| M.Wt | 418.490 | |
| Formula | C17H18N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michelle M Butler, et al. Mol Pharmacol. 2022 Jul 7;MOLPHARM-AR-2022-000549.
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