Catalog No.: PC-24388Not For Human Use, Lab Use Only.
MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species.
MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species. MBX-4132 is highly effective against all tested clinical isolates of N. gonorrhoeae, including MDR strains (N. gonorrhoeae, MIC90=0.34 ug/mL). MBX-4132 is bactericidal against N. gonorrhoeae at concentrations ≥ 4X MIC. MBX-4132 (10 mg/kg) clears infection by a multiple-antibiotic resistant N. gonorrhoeae strain in a murine infection model. MBX-4132 binds to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein bL27.
