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Chemical Structure : MBX2329
CAS No.: 1438272-42-4
Catalog No.: PC-20583Not For Human Use, Lab Use Only.
MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | $898 | In stock | |
| 1 g | Get quote |
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MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).
MBX2329 binds to HA in a nonoverlapping manner, binds to the group 1 HA-specific conformational epitope in the HA stem region.
MBX2329 displays little inhibitory activity against HIV/LASV-GP, HIV/EBOV-GP, or HIV/VSV-G with IC50 values >100 uM.
MBX2329 inhibits influenza A H1N1 virus strains A/PR/8/34 (H1N1), A/Florida/21/2008 (H1N1-H275Y) (oseltamivir-resistant strain), A/Washington/10/2008 (H1N1), and A/California/10/2009 (H1N1) (2009 pandemic strain) with IC50s of 0.29 μM- 0.53 μM.
MBX2329 displays significantly less activity against influenza A H3N2 virus strain A/Texas/12/2007 (H3N2) and influenza B virus strain B/Florida/4/2006.
MBX2329 specifically inhibits influenza viruses of group 1 HA (H1 and H5 subtypes), but not group 2 HA (H3 and H7 subtypes).
MBX2329 exhibit strong synergy with oseltamivir.
| M.Wt | 283.84 | |
| Formula | C16H26ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CCC1=CC=CC=C1OCCN2CCCCCC2.[H]Cl |
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1. Basu A, et al. J Virol. 2014 Feb;88(3):1447-60.
2. Guan S, et al. Sci Rep. 2017 Jun 19;7(1):3786.
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